The clinical impact of reinfection remains incompletely understood. The risk for reinfection also might vary individually based on demographic characteristics, vaccination history, and exposure risk, which are known to be interrelated ( 2, 3). † The number of reinfections is expected to increase as the cumulative incidence of first infections rises, infection- and vaccine-induced immunity wane, and novel variants with increased transmissibility and immune escape characteristics emerge ( 1). To prevent severe COVID-19 outcomes, including those following reinfection, CDC recommends staying up to date with COVID-19 vaccination and receiving timely antiviral treatments, when eligible.*īy September 2021, approximately 150 million total SARS-CoV-2 infections were estimated to have occurred in the United States, suggesting a cumulative incidence of 44% in the population. The median interval between infections ranged from 269 to 411 days by week, with a steep decline at the start of the BA.4/BA.5 period, when >50% of reinfections occurred among persons previously infected during the Alpha variant period or later. Percentages of all COVID-19 cases, hospitalizations, and deaths that were reinfections were consistently higher across variant periods among adults aged 18–49 years compared with those among adults aged ≥50 years. As a percentage of all infections, reinfections increased substantially from the Delta (2.7%) to the Omicron BQ.1/BQ.1.1 (28.8%) periods during the same periods, increases in the percentages of reinfections among COVID-19–associated hospitalizations (from 1.9% to 17.0% ) and deaths (from 1.2% to 12.3% ) were also substantial. Among reported reinfections, weekly trends in the median intervals between infections and frequencies of predominant variants during previous infections were calculated. jurisdictions during September 5, 2021–December 31, 2022, were analyzed overall, by age group, and by five periods of SARS-CoV-2 variant predominance (Delta and Omicron ). Weekly counts of SARS-CoV-2 reinfections, total infections, and associated hospitalizations and deaths reported by 18 U.S. epidemiologic trends in reinfections and associated severe outcomes have not been characterized. Scobie, PhD 1 ( View author affiliations) View suggested citationĪlthough reinfections with SARS-CoV-2 have occurred in the United States with increasing frequency, U.S. Wienkes, MPH 11 Melissa Briggs Hagen, MD 1 Benjamin J. Wang, MPH 19 Lydia Watson-Lewis, MPH 18 Haley N. Tilakaratne, PhD 20 Hailey Vest, MPH 10 Johanna Vostok, MPH 14 Jennifer S. Reed, MSc 7 Elizabeth Slocum, PhD 2 Melissa Sutton, MD 15 Buddhi P. Olsen, MPH 18 Enaholo Omoike, MD, DrPH 17 Komal Patel, MPH 21 Amanda Pettinger, MPH 8 ,22 Melissa A. Morris, MPH 11 John Olmstead, MPH 21 Nina S. Meyer, MPH 11 Lauren Milroy, MPH 10 Keeley J. Jones, MD 1 Grace Kambach, MPH 19 FNU Kanishka, MPH 13 Yuriy Levin 9 John F. Frank, MPH 10 Pauline Harrington, MPH 17 Mikhail Hoskins, MPH 16 Adam Howsare, MPH 18 Lucy M. Falender, DVM 15 Aaron Fleischauer, PhD 16 Darren M. Como-Sabetti, MPH 11 Kevin Cueto, MS 13 Spencer Cunningham, MPH 14 Meredith Eddy, MPH 12 Rebecca A. Bennett 10 Carmen Bernu, MPH 11 Carolyn Chang, MPH 12 Kathryn J. Plumb, MBBS 1 Julia Aiken, MPH 6 Quratul Ain Khanani, MPH 7 Steven Auche, MPH 8 Nagla S. Johnson, DrPH 1 Eli Rosenberg, PhD 3 Joshua A. León, PhD 4 Hannah Henry, MPH 4 Amelia G. Ma, PhD 1 ,2 Vajeera Dorabawila, PhD 3 Tomás M.
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